Dr. Krishnan V

Designation : Professor Higher Academic Grade
School / Centre : Centre for Bio Separation Technology
Department : Biotechnology

Educational Details

Weizmann Institute of Science, Rehovot, ISRAEL

Ph.D.
Biological Chemistry - Thesis title: Defining Initial Steps of Sphingolipid Metabolism in Mammalian Cells.
Graduated in 2003

Post Doctoral Experiences

2003-2008: Postdoctoral Fellow, Centre for Vascular Biology. University of Connecticut Health Cenrtre, Farmington, Connecticut. USA. Postdoctoral Research Supervisor: Prof.Timothy Hla, Patricia K, Donohoe Professor of Surgery, Boston Children’s Hospital, Harvard Medical School, Boston, USA. Field of work: Vascular Biology, Cellular Sources of Sphingosine 1-phosphate, metabolism, transport, signalling pathways regulating vascular endothelial cells.

Research Details

Areas of Specialization
  •  Lipid and Lipoprotein metabolism
  • transport
  • signalling and their relevance to human diseases.  Natural Products Research for Diabetes
  • CVD
  • Obesity.  Molecular Biology and Therapeutic Protein Production- Blood clotting Factor VIII
  • HDL-Apolipoproteins
  • antibody fragments  Anti-Microbial Resistance.  Nutrition and Food Security- Micronutrient such as Vitamin enrichment in functional foods Diabetes
  • Cardiovascular Diseases
  • Obesity
  • Auto-immune dieases

: 0000-0002-2900-8474
: https://www.scopus.com/authid/detail.uri?authorId=7006057214
: https://scholar.google.com/citations?user=-aeEvYcAAAAJ&hl=en&oi=ao
: 21
: 31

Ongoing Funded Project Details

Title Funding Agency
Development of Rapid and high Sensitivity Electrochemical Covid-19 Diagnosis Platform Role: CoinvestigatorICMR, India ICMR, India

Completed Funded Project Details

Title Funding Agency
Cost-effective strategy for the induction of immune tolerance to therapeutic factor VIII in haemophilia A International Grant Govt of India and Govt of France Indo-French Centre for the Promotion of Advanced Research (IFCPAR/CEFIPRA) - Rs.57.4 lakhs For VIT Total outlay 150K Euros - 01-05-2018 To 30-12-2022
High Yielding cell line development of a factor VIII Biosimilar with a novel purification strategy National Biopharma Mission- BIRAC Govt of India - Rs.73.82 lakhs For VIT Total outlay Rs.359.00 lakhs - 20-12-2020 to 19-06-2022
Development of novel process in isolating Aloe vera standardized extract and its application for diabetes control DST-TIFAC Govt of India - Rs.60.58 lakhs - 2011-2014
Intellectual and Industrial Property Issues Challenge Oriented project on “Oxidized HDL-Apolipprotein A1 as a risk predictor of cardiovascular disorders and development of novel diagnostics BIRAC-CEFIPRA-French Embassy (Govt. of India and Govt of France) International Grant - Rs.29.6 lakhs for VIT Total outlay 80K Euros - Arpil 2015- March 2018
Development of a monoclonal antibody-based diagnostic method for the specific detection of COVID-19 viral antigens. DBT-BIRAC - Rs.58.93 lakhs - November 2020 to January 2022

Patent Granted Details

Title Application No.
METHOD FOR PRODUCING RECOMBINANT PEPTIDES AND PROTEIN FROM NON-FILAMENTOUS FUNGI AND RECOMBINANT HOST CELL THEREOF Indian Patent No. 321112; Granted on: 23/09/2019
METHODS FOR PRODUCING RECOMBINANT FACTOR VIII CHAINS FROM NON-FILAMENTOUS FUNGI, THEIR FUNCTIONAL RECONSTITUTION AND APPLICATIONS THEREOF EP2895199A2 ; Granted on 21/08/2019
METHODS FOR PRODUCING RECOMBINANT FACTOR VIII CHAINS FROM NON-FILAMENTOUS FUNGI, THEIR FUNCTIONAL RECONSTITUTION AND APPLICATIONS THEREOF U.S. Patent No. 9,708,387; Granted on 18/07 2017

Books / Book Chapters Published Details

Title Publisher Published Year
COMPOSITION FOR INCREASING VITAMIN B12 IN A FOOD PRODUCT THAT IS CAPABLE OF FERMENTING IN-SITU 2023