Dr. Krishnan V

Designation : Professor Higher Academic Grade
School / Centre : Centre for Bio Separation Technology
Department : Biotechnology

Educational Details

Weizmann Institute of Science, Rehovot, ISRAEL

Ph.D.
Biological Chemistry - Thesis title: Defining Initial Steps of Sphingolipid Metabolism in Mammalian Cells.
Graduated in 2003

University of Agricultural Science, GKVK Campus, Bangalore

M.Sc (Agri)
specialization in Genetics and Plant Breeding
Graduated in 1991

University of Agricultural Science, GKVK Campus, Bangalore

B.Sc (Agri)
Agriculture and allied Sciences
Graduated in 1988

Post Doctoral Experiences

2003-2008: Postdoctoral Fellow, Centre for Vascular Biology. University of Connecticut Health Cenrtre, Farmington, Connecticut. USA. Postdoctoral Research Supervisor: Prof.Timothy Hla, Patricia K, Donohoe Professor of Surgery, Boston Children’s Hospital, Harvard Medical School, Boston, USA. Field of work: Vascular Biology, Cellular Sources of Sphingosine 1-phosphate, metabolism, transport, signalling pathways regulating vascular endothelial cells.

Research Details

Areas of Specialization
  • • Lipids - Lipoprotein metabolism Lipid signalling and transport; and their relevance to human diseases such as CVD; Diabetes; Obesity; Autoimmune diseases especially cardioprotective lipoprotein particles such as HDL and cardiovascular protective lipid sphingosine 1-phosphate
  • Role of Lipoproteins in bacterial and viral diseases
  • Polymorphisms: Positive and Negative gain of function mutations of Lipid transporters; HDL lipoproteins
  • Natural Products Research
  • Molecular Biology and Therapeutic Protein Production- Blood clotting Factor VIII; Antibody fragments; Lipoproteins; anti-obesity protein IRISIN ; Food and nutrition; Vitamin B12 enrichment; functional foods

: 0000-0002-2900-8474
: https://www.scopus.com/authid/detail.uri?authorId=7006057214
: https://scholar.google.com/citations?user=-aeEvYcAAAAJ&hl=en&oi=ao
: 24
: 34

Ongoing Funded Project Details

Title Funding Agency
1. ‘’ApoM lipid interactions in cardiovascular and immune homeostasis: from structural analysis to nano-particle drug delivery”. Seed Grant (RGEMS)
2. Coordinator: Franco-Indian Health Campus (Indian Coordinator for ILIADE project) and Master’s in Biotechnology Twinning Programme MEAE, Govt of France
3. Coordinator: ERASMUS(+) Postgraduate Biotechnology Programme ; students and faculty mobilities. ERASMUS European Union

Completed Funded Project Details

Title Funding Agency
Cost-effective strategy for the induction of immune tolerance to therapeutic factor VIII in haemophilia A International Grant Govt of India and Govt of France Indo-French Centre for the Promotion of Advanced Research (IFCPAR/CEFIPRA) - Rs.57.4 lakhs For VIT Total outlay 150K Euros - 01-05-2018 To 30-12-2022
High Yielding cell line development of a factor VIII Biosimilar with a novel purification strategy National Biopharma Mission- BIRAC Govt of India - Rs.73.82 lakhs For VIT Total outlay Rs.359.00 lakhs - 20-12-2020 to 19-06-2022
Intellectual and Industrial Property Issues Challenge Oriented project on “Oxidized HDL-Apolipprotein A1 as a risk predictor of cardiovascular disorders and development of novel diagnostics BIRAC-CEFIPRA-French Embassy (Govt. of India and Govt of France) International Grant - Rs.29.6 lakhs for VIT Total outlay 80K Euros - Arpil 2015- March 2018
Development of a monoclonal antibody-based diagnostic method for the specific detection of COVID-19 viral antigens. DBT-BIRAC - Rs.58.93 lakhs - November 2020 to January 2022
Development of oral vaccine candidate to reduce the burden of atherosclerosis through recombinant HDL-Apolipoprotein A1 (ApoA1) VIT International Research Fund Scheme (VIN Award)

Patent Published Details

Title Application No.
Composition for increasing vitamin b12 in a food product that is capable of fermenting in-situ. Published on 01-03-2024 Indian Patent Application No. 202441015300; TEMP/E-1/46572/2023-CHE

Patent Granted Details

Title Application No.
METHOD FOR PRODUCING RECOMBINANT PEPTIDES AND PROTEIN FROM NON-FILAMENTOUS FUNGI AND RECOMBINANT HOST CELL THEREOF Indian Patent No. 321112; Granted on: 23/09/2019
METHODS FOR PRODUCING RECOMBINANT FACTOR VIII CHAINS FROM NON-FILAMENTOUS FUNGI, THEIR FUNCTIONAL RECONSTITUTION AND APPLICATIONS THEREOF European Patent No. EP2895199A2 ; Granted on 21/08/2019
METHODS FOR PRODUCING RECOMBINANT FACTOR VIII CHAINS FROM NON-FILAMENTOUS FUNGI, THEIR FUNCTIONAL RECONSTITUTION AND APPLICATIONS THEREOF U.S. Patent No. 9,708,387; Granted on 18/07 2017

Books / Book Chapters Published Details

Title Publisher Published Year
ArunGovind G, Kamalanathan AS, Venkataraman K*. Atherogenic Dyslipoproteinemia in Type Diabetes Mellitus. In Mechanisms of Vascular Defects in Diabetes Mellitus (2017). Ed. C.C. Kartha, Surya Ramachandran, Radhakrishna M. Pillai. Advances in Biochemistry in Health and Diseases. Springer Nature Press. Pp451-467. 2017
Deora and Venkataraman K* Sphingosine 1-phosphate: a versatile bioactive lipid regulating inflammation, barrier function, immune cell trafficking, and cardio protection. In: Inflammation (2020); Volume 1, pp. 181-194.; Chief Eds. Dr.Jyotirmay Biswas, Dr.Chandrashekara S. Society of Inflammation Research. ChanRe Healthcare & Research Pvt.Ltd. India. 2020
Bhale AS, Venkataraman K*. Cholesterol transport by various lipoproteins In: Lipid Analysis in Biology, Health, and Disease. Ed. Sanjoy Bhattacharya. Academic Press is an imprint of Elsevier 125 London Wall, London EC2Y 5AS, United Kingdom; 50 Hampshire Street, 5th Floor, Cambridge, MA 02139, United States Elsevier ELSA (Accepted). (In Press: 2025. ISBN: 978-0-443-19116-9). PP.85-105. 2025